DeVine was born in Waterloo, Iowa,on November 7, 1983 the son of Dennis and Penny DeVine.DeVine was raised in Omaha, Nebraska.He attended Orange Coast College, along with friend and future co-star Blake Anderson.He later moved to Los Angeles, where he began working as a stand-up comedian and actor.
In June 1995, when he was 11 years old, DeVine was walking his bike across a street in Omaha. After he waited for three cement trucks to pass, a fourth truck, previously blocked by opposing traffic, struck him. He went under the first two wheels of the 42-ton truck and slid 500 feet. He was knocked unconscious, suffered acute shock, and fell into a coma. He was rushed to intensive care, where he woke up two weeks later. He had broken all the bones in both of his legs, had a collapsed lung, developed multiple infections, and it was unknown whether he would ever walk again. Over several years, he had 26 surgeries and spent much of the time using a wheelchair. Due to the extent of his injuries, DeVine was at very high risk of having to have his legs amputated, and having multiple organ failure. It was later discovered that the reason he was not killed was because his bike took the full force of the truck.
DeVine regained full mobility but still has extensive scarring on his legs.He said of the accident, "It was really tough because I had to relearn how to walk, stand up, sit up and everything. The legs were totally mangled. I think that experience helped me realize that anything is possible.To pass the time, he would call into his local radio station and impersonate celebrities to entertain himself and others. Upon returning to school, he experienced bullying, but told jokes as a way to deflect attention away from his injuries. He later said that all of this contributed to how he saw comedy as a way of bringing people together.
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